BREAST CANCER BASE

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The United States Jefferson College, Philadelphia and Thomas Jefferson University Kimmel Cancer Center and the Albert Einstein School of Medicine in New York, researchers found in the early play an important role in breast cancer gene mutations, normally, the gene can prevent the development of breast cancer.

"Cancer" Jefferson Medical College biology professor Michael P. Lisanti, Jefferson Kimmel Cancer Center director Richard Pestell, a research team led by Dr. found that nearly 19% of breast cancer patients carry the mutation Caveonlin-1 gene, and usually breast cancer cells by estrogen - therefore call ' estrogen receptor positive 'cells. The group also discovered six new Caveolin-1 gene with the breast cancer. Nearly 35% of the breast cancer patients likely to carry Caveonlin-1 gene mutation. Dr. Lisanti said, Caveonlin information transfer protein in the cell plays an important role, but also with many diseases such as cancer, atherosclerosis, diabetes, secular Mohai the disease and muscular dystrophy.

"" In June 2006 American Journal of Pathology, the researchers reported in this study. They claim that suggested that the results may Caveonlin-1 gene mutations in estrogen-positive breast cancer plays an important role, while 70% of this type of breast cancer.

"" This is the first time on a specific Caveonlin-1 gene mutation specialized and estrogen receptor positive. Dr. Lisanti said he also put in all samples of cancer detection, all the estrogen receptor-negative patients with no Caveonlin mutant gene.

"" "1 / 3 of patients with estrogen receptor-positive Caveonlin carry mutant genes, it is the most common illness among the gene mutation. 'He said,' usually about 70% of patients with breast cancer is estrogen receptor-positive and 30% were negative, which is 1 / 3 of patients with type. "

"" Dr. Lisanti explained that he and his colleagues wanted to test the hypothesis that the "functional Caveonlin-1 gene will lead to the loss of the increase in cancer incidence or increased estrogen receptor expression." Under normal circumstances, only 5-10% of breast cells expression of estrogen receptor, but in some causes cancer and fatal damage receptor activity to be significantly enhanced.

"" Dr. Lisanti group designed missing Caveolin-1 gene in mice, rats found in breast tissue, estrogen receptor number and a significant increase in activity, particularly in mammary epithelial cells, it will stimulate the growth of cells. Dr. Lisanti that Caveolin-1 gene as a switch, controlling receptor activity and cell proliferation.

"" "This is the first time that we found the missing Caveolin gene expression in the upregulation of estrogen receptor plays an important role. This helps to explain the non-lethal to lethal organization into organizations. "Dr. Lisanti explained, estrogen receptor was considered to be useful as gene conversion of certain cyclin D1 gene , which would promote the development of cancer. "We had thought of a breast cancer gene research, prior to this, we would have said that the estrogen receptor gene cyclin D1, which will cause breast cancer. But now we also added another species: caveolin gene inactivation is the first step. "

"" The group found that in patients with breast cancer in the cyclin D1 gene activity increased, especially after receiving estrogen therapy patients. "Essentially, we have designed a pre-clinical models of estrogen in breast cancer development and the role of Caveolin gene deletion, to understanding caveolin gene inactivation as the incidence of breast cancer is the first step in new ways. We have done well. "

"" The group then display the laboratory study, deletion caveolin gene in the mouse mammary cell growth-stimulating factor in the lack of role, estrogen receptor grew. Therefore, they concluded, estrogen receptor up to two factors: Caveolin gene inactivation and growth factor lacking.

"" These findings may have clinical significance. According to Dr. Lisanti said, those estrogen receptor-positive and caveolin gene mutations in breast cancer patients with the gene mutation does not carry caveolin patients than more likely to relapse.

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