BREAST CANCER BASE

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Sweden and the United Kingdom two research team found that a new cell is the target for the prevention and possible treatment of certain key breast cancer.

Up to 5% of breast cancer in women by BRCA1 and BRCA2 mutations lead. These two genes in normal form is under the function of DNA repair may be the fault of the entire DNA sequence to remove and replace the new. They will lead to variations in breast carcinogenesis. The growth of cancer cells might be unstoppable, but in the growth process, they still need to repair their DNA.

Five years ago, the University of Stockholm, Sweden, molecular biologist Thomas Helleday noted, those who can not replace the mistakes of the entire DNA lesion cells can interfere with another DNA repair proteins to kill. This protein called PARP to repair a single DNA base error. Further study showed that PARP gene deletion will not make additional tumors, suggesting that interfering with the role of the protein without affecting normal cells. Helleday of small <BR> Group and the British Cancer Institute Alan Ashworth led another group wished to ascertain in the absence of BRCA cancer cells PARP interference will produce any results.

To this end, Ashworth Group in tissue culture of mouse cells added PARP inhibitor, these cells lack BRCA1 or BRCA2 gene in a particular copy of all two. Join inhibitors for 48 hours, the cells stopped growing, and their chromosomes looked damaged. If the cells to two BRCA genes have at least one copy of the right, subject to PARP inhibitor role beyond normal growth, which means that healthy cells can be well tolerated inhibitors. Hel
Leday team used tissue culture of human breast cancer cells tested, and achieved similar results. Both teams also showed that the BRCA2 gene deletion and cancer of mice, PARP inhibitors can inhibit tumor formation, or the tumor has been reduced.

PARP inhibitor has been approved for other diseases in human safety tests, the researchers believe that using it for breast cancer test may begin within the year. Two groups of papers published in the April 14 "natural" magazine.

University of Sussex, UK cell biologist Keith Caldecott said that the results "very promising", but he also said that to prove the method to control human breast cancer, "there is still a long way to go." Most anticancer drugs to cancer cells grow faster than normal mechanism to play a role in killing the cancer cells also damage healthy cells. The new method can basically do not affect the normal cells, is a no precedent in the way that it is impossible to predict training and whether the mouse results apply to humans.

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