BREAST CANCER BASE

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Breast cancer is the most vicious form of the genetic variation from the stem cells. From Walter and Eliza Ho Institute of Medicine scientists used a small model mice found that breast stem cells have not shown estrogen or progesterone receptors. This and other stem cell characteristics, similar to the deterioration of breast cancer among the basal tumor subtype.

There is increasing evidence that breast cancer is not simply a disease. Scientists will now breast cancer as a heterogeneous disease, each composed of seed type. This has led researchers to speculate that breast cancer may originate from stem cells in the breast.

This possibility caused scientists to understand the composition of normal breast cells of interest. In particular, they wanted to find out whether the breast stem cell performance of estrogen and progesterone receptors and Her2 Zhi markings, which features can be used to define sub-type of breast cancer, and use of the therapy.

Researchers found mice stem cells in the breast of estrogen, progesterone and Her2 receptor has been negative, but these stem cells will show some basal cell markers. These features can also define for basal tumor subtype, which subtype occurred more frequently with the breast cancer gene BRCA1 women.

BRCA1 of human breast cancer cells in the tumor suppressor gene BRCA1 mutations with it the risk of breast cancer than the general population high 8 to 10 times. The family of hereditary breast cancer, BRCA1 mutations up to 40% ~ 50%. In the majority of hereditary breast cancer can be found BRCA1 mutations.

These findings support previous assumptions, breast stem cells or cells very early descent, the basement is the origin of tumor cells. The results of this study will be published in the July 19 issue of the Journal of the National Cancer Institute, China.

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