BREAST CANCER BASE

What is the endocrine treatment, which is preferable to patients with breast cancer endocrine therapy The breast itself is an endocrine organ, the incidence of breast cancer and the body endocrine dysfunction. The endocrine therapy in breast ...

Drug treatment of endocrine characteristics of Endocrine drugs with easy-to-use, fast in extensive clinical applications, and to replace the endocrine glands (ovary, adrenal and pituitary...

Breast cancer and endocrine (particularly ovarian) is close to endocrine therapy in the disease only palliative effect, but in the conservative advanced breast cancer treatment occupy important positions.

Endocrine therapy method : ① hormone use; ② ovariectomy; ③ adrenalectomized; ④ pituitary resection.

(1) Application of hormones : diethylstilbestrol (estrogen) : Each 5 mg orally three times a day, approximately 1 / 3 of patients effectively, especially for soft tissue tumor most noticeable. Efficacy maintain an average of 18 months, up to a few years, some more than five years. In postmenopausal four years or more patients. If there vaginal bleeding or nipple darken such phenomena, namely reductions.

Methyltestosterone (androgen) : intramuscular injection every other day 50 ~ 100 mg (three times a week), the third consecutive six-month, or to people with masculine features, the negative reductions. After the administration two months there curative effect of keeping a hand in some years can be maintained. Not applicable to the five-menopausal or menopausal years have bone metastases within the first phase IV breast cancer patients.

(2) ovariectomy : right breast primary tumor and metastases is a disincentive to the development. Will ovariectomized or after irradiation, around 40% of the patients see the primary cancer and reduce tumor metastasis, the general effect of time to maintain an average of 10 months (3 months to 5 years), the survival period than effectual or extended. Apply to the menopause stage III-IV breast cancer patients.

(3) adrenalectomized : its purpose for the lifting of ovarian follicular endocrine function. Simply Adrenalectomy enable 44% of the patients have eased. The 40 to 50-year-old patients with larger role, the right to relapse after a long time, the slow-growing cancer and urinary estrogen higher volume and bone metastases were more obvious role, or to ease the six months to three years. But surgery devastating advised caution.

(4) removal of pituitary : This treatment of advanced breast cancer by about 1 / 3 to 1 / 2 patients receive mitigation, or mitigation of l to 3 years, to 30 ~ 60-year-old patients with good effect. Right liver metastases and brain metastasis, the evil liquid quality, the enormous local tumor efficacy shew were poor, should not be used.

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Breast cancer endocrine therapy

Breast cancer endocrine therapy option