BREAST CANCER BASE

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Journal of Clinical Oncology, the study, a diameter of less than 1 cm breast lumps acceptable postoperative radiotherapy combined, if a tumor estrogen receptor-positive, a further tamoxifen treatment.

The University of Pittsburgh School of Medicine said Dr. Bernard Fisher, the study seeks to clarify the tumor resection and postoperative radiotherapy in the treatment program right without lymph node metastasis, the diameter of less than 1 cm in invasive breast cancer treatment, but it envisaged the prevention of tamoxifen treatment of breast cancer recurrence after radiotherapy than simply more effective, if and postoperative radiotherapy combined use will play better results.

The researchers selected 1,009 cases of breast cancer patients, the removal of the breast tumor, immediately assigned to receive tamoxifen, radiotherapy and placebo treatment. The results found that tamoxifen group compared to radiotherapy group and the placebo group patients with breast cancer relapse rate reduction of harmful 49%, but the radiation and tamoxifen treatment group relapse rate than harmful radiation group and the placebo group decreased 63%, compared with tamoxifen decreased 81%.

The researchers pointed out that the eight-year follow-up period, the tamoxifen group, radiotherapy group and the placebo group, tamoxifen and chemotherapy treatment group the cumulative recurrence rates were 16.5%, 9.3% and 2.8%. Radiotherapy recurrence rate was below the tamoxifen group, and with estrogen receptor-positive if not. Long-term treatment with low failure rate, the groups showed no significant difference (p = 0.28). The survival rate of all patients between 93% and 94%.

Dr. Fisher, a diameter of less than 1 cm in breast cancer tumor resection alone after high relapse rate, regardless of whether the estrogen receptor positive postoperative radiotherapy should be considered, such as estrogen receptor-positive, but also increase tamoxifen treatment. However, this does not mean that all is less than 1 cm invasive or non-invasive breast cancer patients after resection of the tumor should be given radiotherapy, chemotherapy and tamoxifen, but those supporting the use of the treatment is necessary, according to the individual circumstances of patients, tumor characteristics and whether patients can receive paramedic the side effects of treatment and use, as appropriate.

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