Extended cycle of chemotherapy on breast cancer patients useful
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A 10-year study showed that the node-positive breast cancer before menopause women to accept if epirubicin-based six cycles of chemotherapy, the efficacy is better than three cycles. Cancer spread to the lymph nodes of women, extended treatment time was significantly better disease-free survival. The advantages of combined chemotherapy known for many years, this was the first one on different cancer therapy duration of the test were compared, the researchers said, "this trial clearly showed long-term use of epirubicin, fluorouracil and cyclophosphamide (FEC) treatment, the efficacy was significantly better than short-term therapy. "
The trial published in the January 2003 publication of the "Journal of Clinical Oncology", which 602 cases with lymph node-positive breast cancer in premenopausal women FEC treatment dose intensity and duration of the assessment. These patients were done breast cancer mastectomy or resection of tumor and lymph nodes under the arm removed. After surgery, patients were randomly divided into three groups : epirubicin 50mg/m2 six cycles of FEC, epirubicin 50mg/m2 the FEC three cycles, epirubicin 75mg/m2 three cycles of FEC. With anti-decade results show that low-dose epirubicin 50mg/m2 six cycles without cancer survival rate was significantly higher than three cycles, respectively 53.4% and 42.5%, the dose of 75mg/m2 The survival rate of 43.6%. Three decades group overall survival were : 50mg/m2 FEC six cycles 64.3%, 56.6% 3 cycles, the cycle 75mg/m2 59.7% 3. Researchers said, "long-term follow-dose regardless of the result, the FEC 50mg/m2 six cycles of efficacy in cancer-free survival rates significantly higher than three cycles." As for survival, receive six cycles FEC 50mg/m2 significantly superior efficacy of the three cycles.
Researchers said that the almost three group therapy there were very few serious side effects, and no deaths related to the toxicity of only five people with heart disease, three patients had primitive acute myelogenous leukemia (AML), which is the vice adjuvant chemotherapy response.
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