BREAST CANCER BASE

The U.S. Food and Drug Administration approved paclitaxel for the treatment of early breast cancer     由于该管理局咨询委员会全体成员的一致推荐，今年九月份，美国食品与药物管理局批准，在阿霉素�...

Breast cancer chemotherapy administration results Recently in Beijing at the 2003 new breast cancer treatment at the seminar, from the United States BaylorSammons breast cancer experts in t...

On September 19, 2005, published early online edition of the magazine reported JCO a new solvent-based paclitaxel albumin ABI-007, rescue the treatment of advanced metastatic breast cancer Phase III results of the study.

Advanced metastatic breast cancer patients were randomly divided into two groups, one group of 229 cases, acceptance ABI-007 260mg/m2 three weeks of treatment, the group without preventive treatment; Another group of 225 cases, receive Taxol treatment program administered three weeks, the group takes preventive treatment. Results showed that ABI-007 group than conventional paclitaxel clinical efficiency markedly improved, respectively 33%, 19% (P = .001), and time to tumor progression ABI-007 group than conventional paclitaxel group has significantly extended 23.0,16 respectively. nine weeks (risk ratio = 0.75; P = .006). Toxicity, four degrees neutropenia incidence of ABI-007 significantly reduced, respectively, 9%, 22% (P <.001), although the ABI-007 measurement of intensity than conventional paclitaxel dose increased 49%. Neutropenia fever no difference between the two groups showed rare, less than 2%). 3 degrees sensory nerve pathology in the ABI-007 group more common, were 10%, 2% (P <.001), but handled very easily, and can be eased, and the median number of days for the restoration of 22 days. Although the ABI-007 Group did not conduct routine preventive treatment, but there was no allergic reaction.

Studies show ABI-007 more traditional paclitaxel significantly improve efficacy, safety better. ABI-007 index of the drug treatment is to improve the treatment of advanced metastatic breast cancer the important progress.

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