BREAST CANCER BASE

Bilateral breast cancer refers to bilateral breast simultaneously or in succession of primary breast cancer, breast cancer incidence rate is about 5 ~ 7%. Bilateral simultaneous breast cancer diagnostic criteria : 1 Bilateral mass similar size, no regional lymph node metastasis; ② bilateral without staff members; ③ bilateral able surgery, the skin without lymphatic invasion. In addition, bilateral lesions were above the outside, as one of the diagnostic criteria. Bilateral simultaneous breast-average interval of five to seven years, but the first to the side after treatment for more than three years. Its diagnostic criteria : 1 adjacent to the first cancer diagnosis sure, and had therapy; ② side after the first of at least two years without recurrence; ③ no other parts of distant metastasis. Bilateral basic types of pathology not the same, as both primary cancer diagnosis, but some clinical characteristics can help identify whether the second side of the original cancer or metastases

Breast cancer is the most vicious form of the genetic variation from the stem cells. From Walter and Eliza Ho Institute of Medicine scientists used a small model mice found that breast stem cells have not shown estrogen or progesterone receptors. This and other stem cell characteristics, similar to the deterioration of breast cancer among the basal tumor subtype.

There is increasing evidence that breast cancer is not simply a disease. Scientists will now breast cancer as a heterogeneous disease, each composed of seed type. This has led researchers to speculate that breast cancer may originate from stem cells in the breast.

Mazoplasia higher rate of incidence, breast cancer is often misdiagnosed as breast hyperplasia and delaying treatment. Multiple breast cancer in women after the age of 20, has been an upward trend, and more performance to the upper outer quadrant of breast painless mass, mass for a single or 2 ~ 3, the mass sizes, the general mass from the size of the menstrual cycle, the tumor was irregularly shaped surface is not smooth, nodules were flu, the border is not clear, and more surrounding tissue adhesion, poor mobility, qulaity, was gravel-like hardness. But some breast cancer patients mass smooth surface without nodules flu, and a clear boundary mobility, and with no surrounding tissue adhesion, dynamic observation mass required size changes. Breast cancer patients because of the proliferation faster, Xi'an emerge shortly enlargement of the tumor, mammary hyperplasia and unnecessary features, the main disease mainly to breast pain, breast tenderness nodules obviously, and with close to the menstrual cycle.
In addition, its nipple of breast cancer patients, there may be scaling, erosion or tumor-infiltrating traction there nipple retraction, fixed. Breast Lumps skin surface can arise Orange-like change. Further development of breast cancer can occur local infiltration, armpit and collarbone and upper lymph node metastasis, and even lung, bone, liver, brain and adrenal metastasis.
The breast X-ray, ultrasound examination, near-infrared scans more useful complementary examinations both in the differential diagnosis. Right suspected breast cancer patients should be OK in time fine-needle aspiration biopsy or resection of tumor biopsy for early diagnosis and early treatment.

Proteomics the meaning <BR> genes are the carriers of genetic information, protein is a vital function of the Executive body. Human cells contain some type of protein estimated one million to 10 million species, researchers measured only a small part of the protein sequence. Proteomics to specific cells, tissues or organs contained in the systematic study of protein based on the gene coding for the protein in all subjects, from the cells and research on the overall level of the protein component and its variation, in-depth understanding of the organisms various physiological and pathological processes. Cancer proteomics is right and normal tissue diseases (from precancerous lesions of the tumor) the difference between the expression of the protein identification and quantitative analysis. A cell disease by non-state changes to the process of tumor cells, protein expression profiles will be a series of significant changes, the use of proteomic analysis technology from cell to the overall level shows the changes, to find a specific tumor early diagnosis of biomarkers offers hope.
Proteomics technologies for protein separation and identification. Two-dimensional polyacrylamide gel electrophoresis and mass spectrometry and bioinformatics is the most commonly used of the three technologies. Protein chip technology is a high-throughput analysis method is efficient, quick advantage. Lattice can probe specific protein to capture samples of the target protein and qualitative or quantitative analysis. Antibodies are protein-chip chips, the main types of protein chip is the fastest-growing chip, it becomes increasingly mature, gradually moving towards the industrialization of the production stage. In an experiment can be parallel, high-throughput compared to the same time hundreds of cell types important function of the protein expression changes.